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Foresight Diagnostics Completes Series A Financing to Accelerate Development of its Industry-Leading Minimal Residual Disease (MRD) Technology

  • Results presented at the 2021 ASCO Annual Meeting demonstrate Foresight’s proprietary MRD technology is up to 100-times more sensitive than existing liquid biopsy approaches 
  • Foresight’s novel PhasED-Seq assay enables personalized therapeutic approaches by detecting circulating tumor DNA (ctDNA) at levels as low as one part-per-million 
  • Foresight’s CLIA validated lymphoma MRD assay is first step towards broader applications in the field of oncology

AURORA, COLORADO, Jun 02, 2021 -- Foresight Diagnostics today announced the close of its $12.5M  Series A financing led by Civilization Ventures and Bluebird Ventures, with participation by Pear Ventures, to  commercialize the industry’s most sensitive minimal residual disease (MRD) detection assay. Foresight’s approach is  based on a proprietary technology developed at and licensed from Stanford University called PhasED-Seq (Phased Variant  Enrichment & Detection Sequencing). Based on a simple blood draw and next-generation sequencing, PhasED-Seq screens  for evidence of residual cancer by testing patient plasma samples for the presence of circulating tumor DNA  (ctDNA). 

As reported at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract #7565 and #8518), PhasED-Seq can detect ctDNA at levels as low as one part-per-million, which is up to 100-times more sensitive than other liquid biopsy-based MRD approaches. 

“Foresight’s technology and data demonstrate a level of MRD detection that is more than an order of magnitude better than the nearest competitor, a game changer for the liquid biopsy field,” said Shahram Seyedin-Noor, Founder and General Partner of Civilization Ventures.

Foresight will use the financing to enter the commercial phase of development for the PhasED-Seq technology by launching its first CLIA validated assay to support MRD-driven clinical trials in B-cell lymphomas. In contrast to existing assays, Foresight’s lymphoma MRD offering is an ‘off-the-shelf’ test that does not require tumor tissue or patient-specific customization.

“The unprecedented sensitivity of PhasED-Seq addresses a critical unmet need for how we clinically manage oncology patients. We now have a way to more accurately identify those patients who are not cured with standard treatments, and to direct aggressive and novel therapies accordingly,” said Dr. Max Diehn, a Stanford University professor and co-founder of Foresight. 

“Physicians want to make treatment decisions when disease burden is as low as possible because that is when additional therapy will be most effective,” stated Dr. Ash Alizadeh, a Stanford University professor and co-founder of Foresight, adding: “Existing MRD approaches are simply not sensitive enough for common tumors. We developed Foresight’s MRD test to solve this problem. Following curative intent treatment in patients with B-cell lymphomas our test detected cancer relapse an average of 200 days earlier than standard-of-care imaging approaches with a detection limit below 0.0001%. This earlier detection of disease relapse unlocks several new precision medicine approaches that have potential to significantly improve patient outcomes.” 

Foresight is actively evaluating strategic partnerships and already has multiple studies underway with leading clinical collaborators and pharmaceutical companies. “We’re confident that the PhasED-Seq technology will be an exceptional tool for clinical and drug development applications for a wide array of cancers,” explained Dr. Jake Chabon, co-founder and CEO of Foresight. “We believe that Foresight’s MRD testing platform will become the future standard of care for ctDNA-guided clinical trials which will enable more effective personalized treatment strategies for cancer patients.”

Foresight was founded by Max Diehn (MD/PhD), Ash Alizadeh (MD/PhD), David Kurtz (MD/PhD), and Jake Chabon (PhD), four  prominent Stanford University scientists with a long history of developing cutting-edge innovations in ctDNA  technology. Foresight’s lead investors, Civilization Ventures and Bluebird Ventures, are run by former life science  executives and operators with an outstanding track record of bringing break-through innovations to market. Foresight  has quickly built a world-class team as it enters a new stage of growth, including the addition to its Board of  Directors of Mark Lee (MD/PhD), a founding executive at GRAIL and most recently SVP and Global Head of Personalized  Healthcare at Genentech, and the key hire as CFO and Chief Business Officer of Mukul Agarwal, formerly VP of Corporate  Development at Forty Seven (acquired by Gilead).

About Foresight Diagnostics

Foresight Diagnostics is a privately-held cancer diagnostics company. The company has developed a novel liquid biopsy testing platform for the measurement of minimal residual disease (MRD) that is broadly applicable to a variety of cancers and that is significantly more sensitive than existing tests (with a detection limit below 0.0001% or one part-per-million). This improved sensitivity provides actionable information to physicians and biopharmaceutical companies to enable more personalized treatment approaches for patients. For more information, please visit and follow us on Twitter @ForesightDx and on LinkedIn.

About Civilization Ventures

Civilization Ventures is an early-stage fund focused on supporting innovative companies in the life sciences and healthcare. 

About Bluebird Ventures

Bluebird Ventures is an early-stage life sciences investor, with recent investments including a founding role in Forty Seven, Verinata, and GRAIL.

Contact Foresight

Name: Mukul Agarwal

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